Published on January 8, 2021

Video Friday: Studies show that Vitamin D and Omega-3s may slow or reverse epigenetic aging

Is our age solely determined by the number of years we have lived? While chronological age is calculated the same for everyone (based on how old we are in years), biological age is more representative of overall physiological and functional health, including the risk of age-related conditions and diseases. Epigenetic aging is related to the modification of our genes, specifically through DNA methylation, which may in turn directly affect the biological age of an individual. Research has shown that lifestyle and nutrition factors play a role in epigenetic aging, and that supplementation with specific nutrients may slow or reverse it.

In the video clip below, Dr. Rhonda Patrick interviews Dr. Steve Horvath about evidence suggesting that supplemental vitamin D or omega-3 fatty acids can slow epigenetic aging and add years to our lives.

How Could Vitamin D and Omega-3s Affect Our Biological Age?

Age-related conditions and diseases, including cancers, heart disease, and cognitive disease, can be majorly affected by our lifestyle and nutrition habits. One clear connection is inflammation, which itself has been shown to be a major contributor to aging (termed inflammaging). Both vitamin D and omega-3s have anti-inflammatory effects within the body.

Also common among inflammatory based diseases is the disruption in the tightness and stability of endothelial and vascular tissues. (Endothelial cells form the inner lining of the heart and blood vessels (veins, arteries, capillaries) and the lymphatic system.) This disruption contributes to dysfunctional nutrient exchange, inflammatory cell migration, and abnormal clotting – worsening our biological age. Addressing this disruption has been shown to lessen the effects from the inflammatory diseases involved. Both omega-3s and vitamin D have direct effects on the health of these cells.

Lastly, vitamin D plays a key role in the expression of our genes, and therefore, in the many complex cellular pathways involved throughout the body, in all systems of health.

Watch the Video

After watching the video, be sure to make note of our added details below!

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Here is a quick summary of what this video discusses with some of our added details:

  • A small randomized controlled trial (RCT) by Chen et al. found that vitamin D supplementation of both 2000 IU and 4000 IU per day among 51 overweight and obese African American individuals, who started with vitamin D levels below 20 ng/ml (50 nmol/L), resulted in a significantly decreased amount of epigenetic aging. Vitamin D level was significantly associated with decreased epigenetic aging, regardless of dose.
  • More trials may be needed to further substantiate these findings – but do they need to be randomized controlled trials, or could a large population study do the trick?
  • Supplementation with omega-3 fatty acids also was shown to slow epigenetic aging among 2,174 participants in the Framingham Heart Study. Data from this study also showed that people with the highest Omega-3 Index levels had a lower risk of overall mortality compared to those with the lowest levels
  • A quick mention of the findings of the VITAL trial was at the end of the video, specifying the importance of looking at primary vs secondary outcomes. The VITAL trial focused on cancer and cardiovascular health among those supplementing with vitamin D and omega-3s, and found 30 different very significant results when the separate types of heart disease or death from cancer were analyzed.

Are You Getting Enough Vitamin D and Omega-3s?

Measure your vitamin D level and your omega-3 status with a home blood spot test from GrassrootsHealth. The Omega-3 Index is the key measurement to determine your level of omega-3 fatty acids in the body. Along with the Omega-6:Omega-3 Ratio and the AA:EPA Ratio tests, you can get a clear picture of your omega fatty acid status. Find out if you are you getting enough of both to support your overall health!

By joining the GrassrootsHealth projects, you are not only contributing valuable information to our study, but you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it. Do you know what your status of vitamin D, omega-3s, and other essential nutrients is? Could your levels be improved? Test now to find out!

We now have a NEW GIFTING SERVICE that allows you to quickly send ‘Gift Cards’ to friends, family and coworkers who you consider might need immediate access to testing, and to Claim the Joy of Your Health TODAY. Give the gift today!

What does the Research Say about Vitamin D & COVID-19?

It’s TIME to start saving lives! If you can help PREVENT the majority of the death, it’s time! What’s it costing you/us not to take action NOW?

There is much published research that supports a clear link between vitamin D and COVID-19 showing that higher vitamin D levels are related to:

a decreased risk of testing positive for COVID-19

increased viral SARS-CoV-2 RNA clearance

better clinical outcomes among patients with COVID-19

less severe COVID-19 disease

decreased risk of death due to COVID-19

Be sure to educate yourself on the benefits and importance of vitamin D for immune health, and take steps to ensure you and your loved ones are getting enough.

You can review all of the COVID-19 and immune health information we have shared on this page.

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.


The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!