Multiple sclerosis (MS) is a chronic, neurodegenerative autoimmune disease characterized by the production of antibodies against the myelin sheath of the brain tissue and spinal cord. Myelin sheath insulates neurons and is responsible for the rapid transmission of electrical signals from one nerve cell to another. In MS, the immune system attacks and destroys myelin sheath resulting in loss of neuronal function and symptoms such as loss of balance, numbness, muscle weakness, fatigue, chronic pain and depression.
GrassrootsHealth has covered the relationship between sun exposure and lower risk of MS as well as fish consumption and lower risk of demyelination. However, the combined effect of vitamin D and omega-3 fatty acid co-supplementation on MS has yet to be discussed.
Findings from a Recent Study
A 2018 randomized, placebo-controlled study by Kouchaki et al. examined the effect of co-supplementing with vitamin D and omega-3 fatty acids on disability status and inflammation in patients with MS. A total of 53 patients with relapsing-remitting MS between the ages of 18-55 years were randomly assigned to either a placebo group (n=27) or treatment group (n=26). The treatment group received omega-3 fatty acid capsules twice daily (each containing 500 mg of DHA and 106 mg of EPA) and 50,000 IU of vitamin D twice per week for 12 weeks; whereas the placebo group received sunflower oil capsules daily for 12 weeks.
Compliance with taking the supplements was greater than 90% in both groups and there were no side effects reported throughout the study. After 12 weeks, the treatment group reported significant improvements in disability (measured using the Expanded Disability Status Scale [EDSS]) (P = 0.01) and inflammation. Inflammation was assessed by measuring blood levels of high-sensitivity C-reactive protein, plasma total antioxidant capacity, total glutathione, and malondialdehyde (markers of oxidative stress). Furthermore, co-supplementation with vitamin D3 and omega-3 fatty acids resulted in significant reduction in serum insulin levels.
In summary, omega-3 fatty acid and vitamin D co-supplementation were meaningful interventions due to their association with improved antioxidant capacity, inflammation status, glycemic control, and disability status in patients with relapsing-remitting MS.
Could Your Levels of Inflammation Improve with Vitamin D and Omega-3s
By testing your inflammation and nutrient levels and taking steps to improve the status of each, you may also be benefiting your overall health. With your data and results, we are also able to analyze, find, and publish nutrient research that can be applied to your life and others’. You can also track your own intakes, symptoms and results to see what works best for YOU.
Make sure you know your vitamin D level, and take steps to keep it within a target of 40-60 ng/ml or 100-150 nmol/L! Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.
Make sure you track your results before and after, about every 6 months!
How can I track my nutrient intake and levels over time?
To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called
For each specific supplement, you can track what days you take it, how much, and many other details. This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!