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Published on August 30, 2021

Could taking certain medications alter vitamin D metabolism and status?

There are several factors that can affect vitamin D levels for individuals, besides vitamin D intake and sun exposure, including a person’s age, skin color, genetics, where they live, and certain chronic diseases. Digestive disorders can decrease the absorption of vitamin D, resulting in a lower vitamin D level, as can a lack of specific co-nutrients, such as magnesium. Also, some medications including statins, prednisone and weight-loss drugs, can block vitamin D absorption and/or metabolism, increasing the risk of low vitamin D levels and vitamin D deficiency.

How Can Medications Impact Vitamin D Levels?

There are several ways in which medications may affect the absorption, metabolism, and regulation of vitamin D. For example, the same enzyme (25-hydroxylase CYP3A4) that metabolizes about half of all medications is responsible for transforming supplemental vitamin D3 and D2 to 25(OH)D. Also, since vitamin D is a fat-soluble vitamin, certain medications that block dietary fat absorption or enhance its elimination may also have a negative effect on vitamin D absorption, therefore increasing the risk of deficiency.

More People Taking Multiple (5 or More) Medications at a Time

With an increased number of medications taken by an individual concurrently, the risk of those medications having an effect on their vitamin D level also increases. According to a review by Wakeman, M, there has been a significant increase over the past couple decades of individuals taking five or more medications at any given time. This is especially prevalent among the elderly (those ages 65 years and older). In fact, in the UK alone, the percentage of elderly taking five or more medications increased from 12% to 49%; a 4-fold increase over two decades. This increased use of medication among the elderly is especially concerning, since the risk of vitamin D deficiency increases with age.

One study in particular looked at the relationship between the risk of vitamin D deficiency and the number of medications being taken among 1000 community-dwelling Dutch citizens. 49% of the population was vitamin D deficient, with levels below 20 ng/ml or 50 nmol/L. When looking at levels among those who did not take a vitamin D supplement, the use of multiple medications was found to be a significant factor in negatively affecting vitamin D levels.

What Medications Might Affect Vitamin D?

The table below contains a list of medications and their potential effects on vitamin D, as reviewed by Wakeman.

Click to Enlarge & Print

Importance of Measuring Vitamin D When on Certain Medications

In conclusion, the authors stress the importance of monitoring vitamin D levels and supplementing as necessary “with the objective of achieving adequate levels of vitamin D while also optimizing the efficacy of treatment and limiting drug side-effects and toxicity.”

Are Your Vitamin D Levels OK?

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure, such as your vitamin D, omega-3s, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

Help everyone Move Research into Practice with vitamin D and other nutrients! As a special birthday gift to everyone, in honor of the science, we have created a special scholarship fund for anyone to donate to that will go towards helping others participate. Your donation will allow anyone to get help with funding their participation when they need it.

Text-to-give: Text Daction to 44321 to add to our Scholarship Fund.

How Can You Use this Information for YOUR Health?

Having and maintaining healthy vitamin D and other nutrient levels can help improve your health now and for your future. Measuring is the only way to make sure you are getting enough!

STEP 1 Order your at-home blood spot test kit to measure vitamin D and other nutrients of concern to you, such as omega-3s, magnesium, essential and toxic elements (zinc, copper, selenium, lead, cadmium, mercury); include hsCRP as a marker of inflammation or HbA1c for blood sugar health

STEP 2 Answer the online questionnaire as part of the GrassrootsHealth study

STEP 3 Using our educational materials and tools (such as our dose calculators), assess your results to determine if you are in your desired target range or if actions should be taken to get there

STEP 4 After 3-6 months of implementing your changes, re-test to see if you have achieved your target level(s)

Enroll in D*action and Build Your Custom Test Kit!