Published on February 11, 2019

There was a song that was on a 78 record that I had as a child, The Churkendoose (yes, I’m really that old..)

Well It depends upon, begins and ends upon,
It depends on how you look at things!

How nutrient trial design affects results and outcome

The vitamin D research community is literally ‘shooting itself in the foot’ by reporting trial results solely on dosage groups without also always showing the serum level analyses. The dose/response variation as shown in our research and that of others shows a very large variation, a factor of six in terms of response. One person can take 2000 IU/day and get to 20 ng/ml (50 nmol/L), another can take exactly the same amount, 2000 IU/day, and get to 120 ng/ml (300 nmol/L).

If, for example I had two people taking 2000 IU/day and one got to 20 ng/ml, the other to 120 ng/ml, I’d tell you the average was 70 ng/ml.

If we had another group taking 4000 IU/day and both got to 70 ng/ml, I’d tell you the average was 70 ng/ml.

We’d then say that there was ‘no difference’ in the two doses. Really? And, we’d expect no significant difference in the health outcomes?

Please look at the chart below to see how that scenario looks with the Hollis/Wagner pregnancy study (left hand side of the chart shows results by intake).

Click to Download & Print

An almost ‘flat’ health outcome chart when looked at by intake level.When we look at the same patients by serum level vs intake, there is a very large difference.


Carole Baggerly, Director

How can I track my vitamin D level and health?

To help you track your nutrient levels and health outcomes, GrassrootsHealth has created an online tracking system called myData-myAnswers. You can track details about your supplement use and nutrient levels. You can also track many pre-set health conditions, such as cognitive function, or add your own custom trackers. This will help you discover how your nutrient levels impact your health. Check it out today!

Click Here

How Can You Use this Information for YOUR Health?

Having and maintaining healthy vitamin D and other nutrient levels can help improve your health now and for your future. Measuring is the only way to make sure you are getting enough!

STEP 1 Order your at-home blood spot test kit to measure vitamin D and other nutrients of concern to you, such as omega-3s, magnesium, essential and toxic elements (zinc, copper, selenium, lead, cadmium, mercury); include hsCRP as a marker of inflammation or HbA1c for blood sugar health

STEP 2 Answer the online questionnaire as part of the GrassrootsHealth study

STEP 3 Using our educational materials and tools (such as our dose calculators), assess your results to determine if you are in your desired target range or if actions should be taken to get there

STEP 4 After 3-6 months of implementing your changes, re-test to see if you have achieved your target level(s)

Enroll in D*action and Build Your Custom Test Kit!