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Published on November 8, 2021

New study shows significant relationship between changes in vitamin D levels and changes in lipid levels, with decreasing vitamin D linked to worsening lipid profile

Key Points

  • A year to year comparison found a significant decrease in TC, LDL-C, and TG levels among individuals whose vitamin D level had increased by 10 ng/ml or more, and an increase in TC, LDL-C, and TG levels among those whose vitamin D level had decreased by 10 ng/ml or more
  • Changes in HDL-C were observed alongside changes in vitamin D levels, but these changes were slight and not statistically significant for all groups
  • This study supports previous research showing that reductions in vitamin D levels are associated with worsening lipid profiles, and the authors suggest that vitamin D supplementation may be of benefit for individuals with dyslipidemia

Several questions about vitamin D and cholesterol levels have been asked of us in the past, such as “Does increasing my vitamin D level or supplementing with vitamin D raise cholesterol levels,” or “Do vitamin D levels change with cholesterol levels?” While there have been a small handful of studies and trials on the subject, we have not had any specific answers for those questions up until this point. A paper recently published helps to shed light on the topic, and is reviewed below.

Real-World Data Reveals Relationship between Year to Year Changes in Vitamin D and Lipid Levels

In an effort to further clarify the relationship between vitamin D and lipid levels, Li et al. analyzed data from a real-world setting, using laboratory measurements obtained from an annual employee health program. Their goal was to see if there was a consistent, significant relationship between year-to-year increases or decreases in vitamin D levels and changes in serum lipid levels. They split the data into cohorts according to year:

  • Cohort 1 contained measurements from 5580 individuals for the years 2017 to 2018
  • Cohort 2 contained measurements from 6057 individuals for the years 2018 to 2019
  • Cohort 3 contained measurements from 7249 individuals for the years 2019-2020

Each cohort was split into two different groups – those whose vitamin D level increased by 10 ng/ml (25 nmol/L) or more from one year to the next, and those whose vitamin D level decreased by 10 ng/ml or more. Changes in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were also evaluated for each of the two groups within each cohort.

Increasing Vitamin D Levels Linked to Decreased Cholesterol Measures

For each year to year comparison, the authors found a significant decrease in TC, LDL-C, and TG levels among those whose vitamin D level had increased by 10 ng/ml or more. They also found a significant increase in TC, LDL-C, and TG levels among those whose vitamin D level had decreased by 10 ng/ml or more.

Click to Enlarge & Print

As can be seen in the chart above, where orange bars indicate decreasing vitamin D levels and green bars indicate increasing vitamin D levels, TC, LDL-C, and TG levels increased (worsened) when the vitamin D level went down by at least 10 ng/ml (25 nmol/L) over the year, and decreased (improved) when vitamin D level went up by at least 10 ng/ml over the year.  For those whose vitamin D levels increased by 10 ng/ml (25 nmol/L) or more, compared to those whose levels decreased, there was an approximate reduction in

  • Total Cholesterol by 10-12 mg/dL
  • LDL-C by 7-8 mg/dL
  • And Triglycerides by 21-28 mg/dL

These changes remained significant even after adjusting for age, sex, race, education, BMI, blood pressure, smoking status, geographical location, vitamin D level at baseline, and lipid level at baseline. While changes in HDL-C were observed, these changes were slight and not statistically significant for all groups.

In summary, this study showed that

“individuals who had year-over-year increases in vitamin D levels tended to have corresponding decreases in levels of TC, LDL-C, and TG. Conversely, individuals who had year-over-year decreases in vitamin D levels tended to have increases in TC, LDL-C, and TG levels.”

These findings support previous research showing that reductions in vitamin D levels are associated with worsening lipid profiles, and with this, the authors suggest that vitamin D supplementation may be of benefit for individuals with dyslipidemia.

Vitamin D is an Easily Modifiable Factor to Help Improve Disease Outcomes – Make Sure You Are Getting Enough

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure, such as your vitamin D, omega-3s, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.

NEWS ALERT

The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!