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Published on October 28, 2021

New study on individuals with cardiovascular disease shows that those with higher levels of vitamin D were less likely to die from all causes over an 11 year follow-up period

Key Points

  • A recent study among individuals with cardiovascular disease found that death from all causes (including heart disease, and especially cancer) was significantly associated with vitamin D level
  • For every 4 ng/ml (10 nmol/L) increase in vitamin D level was associated with a 12% reduction in risk for all-cause mortality and a 9% reduced risk for CVD mortality
  • The effect of vitamin D level on mortality remained even after adjusting for age, sex, alcohol, BMI, glomerular filtration rate (GFR), education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol

A new, large-scale observational study by Dai et al., which included data from 37,079 people in the UK with existing cardiovascular disease (CVD), ages 40-69 years, found that death from all causes (including heart disease, and especially cancer) was significantly associated with vitamin D level.

Over the study period, there were a total of 6,319 deaths; 2161 deaths from CVD, 2230 deaths from cancer, 623 deaths from respiratory diseases, and 1305 deaths from other causes.

Those with vitamin D deficiency (levels less than 20 ng/ml or 50 nmol/L) had the greatest potential for reduced risk of death. In fact, for these individuals, every 4 ng/ml (10 nmol/L) increase in vitamin D level was associated with a 12% reduction in risk for all-cause mortality and a 9% reduced risk for CVD mortality. This means that, for those whose vitamin D level started below 20 ng/ml, increasing their vitamin D level by 20 ng/ml (50 nmol/L) could reduce their risk of death from all causes by 47%, and reduce their risk of death from CVD by 38%.

Dr. John Campbell Gives an Excellent Overview of this Study

Watch the video for an excellent explanation of the study and its findings, and read the notes below.

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Notes from the Video

  • Vitamin D deficiency is a concern especially during this time of year and the coming winter season, when many in the northern hemispheres are not able to produce any or enough vitamin D from the sun available
  • A new study by Dai et al. found that death from all causes among individuals with CVD was significantly associated with vitamin D level – indicating that vitamin D could be protective
  • CVD included coronary heart disease, atrial fibrillation, heart failure, and stroke
  • 57.5% of the participants were vitamin D deficient at baseline (<20 ng/ml)
  • During the median follow-up time of 11.7 years, there was a total of 6,319 deaths; causes of death were from CVD, cancer, respiratory disease, and other causes
  • The authors found a non-linear inverse association for each cause of death – deaths increased as vitamin D decreased, and the findings were significant

Click to Enlarge & Print

  • As illustrated in the chart above on the adjusted hazard ratio of all-cause mortality, anything above 1 is increased risk of death, anything below 1 is decreased risk of death. For example, where the line crosses 1.25, it is a 25% increased risk of death at that vitamin D level
  • Risk of all-cause death was greatest with very low levels, with the risk flattening around 30-40 ng/ml (75-100 nmol/L)
  • Risk of cardiovascular mortality continued to decrease with increasing vitamin D levels
  • For every 10 nmol/L (4 ng/ml) increase in vitamin D level, there was an associated 12% reduction in risk for all-cause mortality and 9% reduced risk for CVD mortality
  • The effect of vitamin D level on mortality remained even after adjusting for age, sex, alcohol, BMI, glomerular filtration rate (GFR), education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterol

Could Maintaining a Higher Vitamin D Level Help Extend Your Life?

This is yet another study demonstrating the prognostic significance of vitamin D, in this case, on the risk of death over time.

Don’t ever consider a situation too late to take steps for correcting or avoiding vitamin D deficiency. Measuring your vitamin D level and calculating a supplementation amount to help reach and maintain a target level, or taking loading doses to correct deficiency faster, could possibly make all the difference in how a current disease situation progresses. Test your level now!

Vitamin D is an Easily Modifiable Factor to Help Improve Disease Outcomes – Make Sure You Are Getting Enough, Especially in the Upcoming Seasons

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure, such as your vitamin D, omega-3s, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.

NEWS ALERT

The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!