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Published on February 15, 2022

Study finds strong correlation between COVID-19 severity and pre-infection vitamin D level, especially for patients 50 years or older

Key Points

  • A new study looked at pre-infection vitamin D levels among 253 patients hospitalized with COVID-19, and compared those levels to COVID-19 disease severity
  • Patients were divided into four categories based on their measured pre-infection vitamin D level and their vitamin D level predicted for their month of COVID-19 diagnosis; the category distribution and the findings were similar for both groups
  • The study found that 57% of those with pre-infection vitamin D levels below 20 ng/ml ended up with severe or critical COVID-19, severe or critical COVID-19 was 87% less likely among patients whose pre-infection vitamin D level was at least 40 ng/ml compared to below 20 ng/ml, and patients with pre-infection vitamin D levels below 20 ng/ml were 14 times more likely to have severe/critical COVID-19 compared to those at or above 40 ng/ml
  • Further analysis found the strongest correlation between vitamin D level and COVID-19 disease severity among those who were 50 years or older

Many studies have now been published showing a clear association between vitamin D levels and the risk and severity of COVID-19 disease.

Another study by Dror et al. looked at pre-infection vitamin D levels among 253 patients hospitalized with COVID-19, and compared those levels to COVID-19 disease severity. Vitamin D levels had been measured anywhere from 14 to 730 days prior to COVID-19 diagnosis, and a statistical model was used to account for seasonal variability and predict the average vitamin D level of each patient by year and month. Patients were divided into four categories based on their measured pre-infection vitamin D level and their vitamin D level predicted for their month of COVID-19 diagnosis; the category distribution and the findings were similar for both groups.

What did the study find?

Based on the measured pre-infection vitamin D levels, over half had levels below 20 ng/ml (50 nmol/L). When divided into categories, 52.5% of patients were below 20 ng/ml (50 nmol/L), 14.2% were between 20 and 29.9 ng/ml (50-74.9 nmol/L), 17.3% were 30-39.9 ng/ml (75-99.9 nmol/L), and 15.8% had levels of 40 ng/ml (100 nmol/L) or higher.

In this analysis, the authors found that

57% of those with pre-infection vitamin D levels below 20 ng/ml ended up with severe or critical COVID-19,

severe/critical COVID-19 was 87% less likely among patients whose pre-infection vitamin D level was at least 40 ng/ml compared to below 20 ng/ml (p<0.001),

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patients with pre-infection vitamin D levels below 20 ng/ml were 14 times more likely to have severe/critical COVID-19 compared to those at or above 40 ng/ml (p<0.001),

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and the COVID-19 mortality rate among those with pre-infection vitamin D levels below 20 ng/ml was 25.6% compared to 5% or lower in the patients with higher vitamin D levels (p<0.001).

The analysis using the predicted vitamin D level at the month of COVID-19 diagnosis showed consistently similar results to those using the actual measurements – that COVID-19 disease severity worsened with lower predicted vitamin D levels.

Age Affected Strength of Correlation between Vitamin D and COVID Severity

Besides vitamin D level, age was also a consistently independent risk factor for severe COVID-19 disease. In fact, further analysis found the strongest correlation between vitamin D level and COVID-19 disease severity among those who were 50 years or older (p<0.001), although the relationship was significant for the younger age groups as well.

What is YOUR Vitamin D Level?

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure with vitamin D, such as your Omega-3 Index, omega fatty acid ratios, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.

NEWS ALERT

The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!